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This family accommodates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, besides histone, a variety of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and elements of the TATA binding protein (TBP) complicated, TBP-related elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-Okay (target lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of eradicating the methyl mark on most of these substrates 17 , ninety four Due to this fact KMT7/KDM1A has emerged as a basic mannequin for dynamic lysine methylation of both histone and non-histone proteins. | |||
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