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The enzymes concerned in lysine methylation have been first found to focus on histone and thus were initially named histone methyltransferases and histone demethylases, following the naming model for histone acetyltransferase and histone deacetylase. KMTs catalyze mono-, di-, or tri-methylation by transfering one, two, or three methyl teams, respectively, from S-adenosyl-L-methionine to the ε-amino group of a lysine residue. | |||||
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Methylation of proteins from budding yeasts (similar to Ipl Aurora kinase and ribosomal proteins) and vegetation (Rubisco subunits) has also been reported eleven , 183 - 185 It is conceivable that many proteins may be modified by lysine methylation, along with other forms of PTMs. The lysine 831 of vascular endothelial development issue receptor 1 is a novel target of methylation by SMYD3. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. | |||||
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